换一批
换一批Biosynthesis of Neocarazostatin A Reveals the Sequential Carbazole Prenylation and Hydroxylation in the Tailoring Steps.
作者：
Sheng,Huang [1]
;
Somayah Sameer,Elsayed [2]
;
Meinan,Lv [1]
;
Jioji,Tabudravu [2]
;
Mostafa E,Rateb [3]
;
Roland,Gyampoh [4]
;
Kwaku,Kyeremeh [4]
;
Rainer,Ebel [2]
;
Marcel,Jaspars [2]
;
Zixin,Deng [1]
;
Yi,Yu [5]
;
Hai,Deng [6]
作者单位：
Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Ministry of Education), School of Pharmaceutical Sciences, Wuhan University, 185 East Lake Road, Wuhan 430071, P.R. China.
[1]
Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, UK.
[2]
Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, UK; Pharmacognosy Department, School of Pharmacy, Beni-Suef University, Beni-Suef 32514, Egypt.
[3]
Department of Chemistry, University of Ghana, P.O. Box LG56, Legon-Accra, Ghana.
[4]
Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Ministry of Education), School of Pharmaceutical Sciences, Wuhan University, 185 East Lake Road, Wuhan 430071, P.R. China. Electronic address: yu_yi@whu.edu.cn.
[5]
Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, UK. Electronic address: h.deng@abdn.ac.uk.
[6]
期刊：
《Chemistry & biology》
2015年22卷12期1633-42页
关键词：
P450 enzyme;biosynthesis;carbazole alkaloids;neocarazostatin A;prenyltransferase;reconstitution
主题词：
生物合成途径(Biosynthetic Pathways);卡唑类(Carbazoles);色谱法, 高压液相(Chromatography, High Pressure Liquid);克隆, 分子(Cloning, Molecular);大肠杆菌(Escherichia coli);羟基化(Hydroxylation);分子序列数据(Molecular Sequence Data);分子结构(Molecular Structure);异戊烯化(Prenylation);串联质谱法(Tandem Mass Spectrometry)
DOI：
10.1016/j.chembiol.2015.10.012
PMID：
26670080
发布时间：
2015-12-21
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