Enabling site-specific NMR investigations of therapeutic Fab using a cell-free based isotopic labeling approach: application to anti-LAMP1 Fab.
作者:
Arthur,Giraud [1]
;
Lionel,Imbert [2]
;
Adrien,Favier [3]
;
Faustine,Henot [1]
;
Francis,Duffieux [1]
;
Camille,Samson [1]
;
Oriane,Frances [2]
;
Elodie,Crublet [2]
;
Jérôme,Boisbouvier [2]
作者单位:
Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), 71, Avenue des Martyrs, 38044, Grenoble, France.
[1]
Sanofi Research & Development, 94403, Vitry-sur-Seine, France.
[2]
NMR-Bio, 5 place Robert Schuman, 38025, Grenoble, France.
[3]
Sanofi Research & Development, 94403, Vitry-sur-Seine, France. Oriane.Frances@sanofi.com.
[4]
NMR-Bio, 5 place Robert Schuman, 38025, Grenoble, France. crublet@nmr-bio.com.
[5]
Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), 71, Avenue des Martyrs, 38044, Grenoble, France. jerome.boisbouvier@ibs.fr.
[6]
期刊:
主题词:
免疫球蛋白Fab片段(Immunoglobulin Fab Fragments);核磁共振, 生物分子(Nuclear Magnetic Resonance, Biomolecular);同位素标记(Isotope Labeling);人类(Humans);无细胞系统(Cell-Free System);氮同位素(Nitrogen Isotopes);抗体, 单克隆(Antibodies, Monoclonal)
DOI:
10.1007/s10858-023-00433-4
PMID:
38546905
发布时间:
2024-06-27
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