换一批
换一批Molecularly guided therapy versus chemotherapy after disease control in unfavourable cancer of unknown primary (CUPISCO): an open-label, randomised, phase 2 study.
作者：
Alwin,Krämer [1]
;
Tilmann,Bochtler [2]
;
Chantal,Pauli [3]
;
Kai-Keen,Shiu [4]
;
Natalie,Cook [5]
;
Juliana Janoski,de Menezes [6]
;
Roberto A,Pazo-Cid [7]
;
Ferran,Losa [8]
;
Debbie Gj,Robbrecht [9]
;
Jiří,Tomášek [10]
;
Cagatay,Arslan [11]
;
Mustafa,Özgüroğlu [12]
;
Michael,Stahl [13]
;
Frédéric,Bigot [14]
;
Sun Young,Kim [15]
;
Yoichi,Naito [16]
;
Antoine,Italiano [17]
;
Nasséra,Chalabi [18]
;
Gonzalo,Durán-Pacheco [18]
;
Chantal,Michaud [18]
;
Jeremy,Scarato [18]
;
Marlene,Thomas [18]
;
Jeffrey S,Ross [19]
;
Holger,Moch [3]
;
Linda,Mileshkin [20]
作者单位：
Clinical Cooperation Unit Molecular Hematology-Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany. Electronic address: a.kraemer@dkfz-heidelberg.de.
[1]
Clinical Cooperation Unit Molecular Hematology-Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.
[2]
Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland; Department of Pathology and Molecular Pathology, University Hospital of Zurich, Zurich, Switzerland; Medical Faculty, University of Zurich, Zurich, Switzerland.
[3]
UCLH Gastrointestinal Oncology Service, Cancer of Unknown Primary Service, University College London, Cancer Institute, London, UK.
[4]
The Christie NHS Foundation Trust and Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
[5]
Clinical Oncology, Centro Integrado de Pesquisa em Oncologia, Porto Alegre, Brazil.
[6]
Medical Oncology Department, Miguel Servet University Hospital, Zaragoza, Spain.
[7]
Medical Oncology Department, Hospital de Sant Joan Despí Moisès Broggi, ICO Hospitalet, Barcelona, Spain.
[8]
Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands.
[9]
Masaryk Memorial Cancer Institute, Brno, Czech Republic.
[10]
Izmir University of Economics Medical Point Hospital, Izmir, Türkiye.
[11]
Istanbul University Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Internal Medicine, Division of Oncology, Istanbul, Türkiye.
[12]
Evang Kliniken Essen-Mitte, Essen, Germany.
[13]
Department of Medical Oncology, Institut de Cancérologie de l'Ouest, Angers, France.
[14]
Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
[15]
Department of General Internal Medicine, National Cancer Center Hospital East, Kashiwa, Japan.
[16]
Institut Bergonie, Early Phase Trials and Sarcoma Units, Bordeaux, France.
[17]
Global Product Development Medical Affairs, F Hoffmann-La Roche, Basel, Switzerland.
[18]
Pathology Group, Foundation Medicine, Cambridge, MA, USA; Upstate Medical University Departments of Pathology, Urology and Medicine (Oncology), Syracuse, NY, USA.
[19]
Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
[20]
期刊：
主题词：
人类(Humans);肿瘤, 未知原发灶(Neoplasms, Unknown Primary);女(雌)性(Female);男(雄)性(Male);中年人(Middle Aged);老年人(Aged);抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);前瞻性研究(Prospective Studies);成年人(Adult);分子靶向治疗(Molecular Targeted Therapy);腺癌(Adenocarcinoma)
DOI：
10.1016/S0140-6736(24)00814-6
PMID：
39096924
发布时间：
2024-08-12
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