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The creation of 3D nanofibers offering desirable functions for bone regeneration is developed due to the latest improvisa-tions to the electrospinning technique.Synthetic polymers are among the best choices for medical usage due to their lower costs,high tensile properties,and ease of spinnability compared to natural polymers.In this communication,we report a series of interventions to polymers modified with Mg-based fillers for ideal tissue engineering applications.The literature survey indicated that these filler materials(e.g.,nano-sized particles)enhanced biocompatibility,antibacterial activity,tensile strength,and anti-corrosive properties.This review discusses electrospinning parameters,properties,and applica-tions of the poly(ε-caprolactone),poly(lactic acid),poly(3-hydroxybutyric acid-co-3-hydroxy valeric acid),polyurethane,and poly(vinyl pyrrolidone)nanofibers when modified with Mg-based fillers.This report encourages researchers to use synthetic polymers with Mg as fillers and validate them for tissue engineering applications.