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目的:探讨非酒精性脂肪性肝病（non-alcoholic fatty liver disease, NAFLD）对急性缺血性卒中（acute ischemic stroke, AIS）患者转归的影响。方法:回顾性纳入2017年6月至2023年12月间在南京医科大学附属江宁医院就诊的AIS患者。在发病后3个月时应用改良Rankin量表评价转归，0~2分定义为转归良好，>2分定义为转归不良。采用多变量 logistic回归分析确定NAFLD对AIS患者转归的影响。 结果:共纳入143例AIS患者，男性95例（66.43%），年龄（67.79±11.15）岁。96例（67.13%）转归良好，47例（32.87%）转归不良。多变量 logistic回归分析显示，校正混杂因素后，NAFLD与AIS患者转归不良独立相关（优势比2.500，95%置信区间1.015~6.161； P=0.046）。 结论:NAFLD是AIS患者转归不良的独立危险因素。

Objective:To investigate the impact of non-alcoholic fatty liver disease (NAFLD) on the outcome of patients with acute ischemic stroke (AIS).Methods:Patients with AIS visited the Affiliated Jiangning Hospital of Nanjing Medical University between June 2017 and December 2023 were included retrospectively. At 3 months after onset, the modified Rankin Scale was used to evaluate the outcome, with scores of 0-2 defined as good outcome and >2 defined as poor outcome. Multivariate logistic regression analysis was used to determine the impact of NAFLD on the outcome of patients with AIS. Results:A total of 143 patients with AIS were enrolled, including 95 males (66.43%), aged 67.79±11.15 years. Ninety six patients (67.13%) had good outcome, and 47 (32.87%) had poor outcome. Multivariate logistic regression analysis showed that after adjusting for confounding factors, NAFLD was independently associated with the poor outcome in patients with AIS (odds ratio 2.500, 95% confidence interval 1.015-6.161; P=0.046). Conclusion:NAFLD is an independent risk factor for poor outcome in patients with AIS.