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替度鲁肽（teduglutide，TED）是一种新型重组的胰高血糖素样肽-2（glucagon like peptide-2，GLP-2）类似物，GLP-2可促进小肠营养物质转运、增加小肠血流量、促进隐窝细胞增殖、抑制隐窝细胞凋亡和增强小肠屏障功能。短肠综合征（short bowel syndrome，SBS）成人患者应用TED后，肠外营养（parenteral nutrition，PN）的使用时间和剂量均减少。本研究对GLP-2和TED作用机制以及小儿SBS治疗过程中的有效性和安全性进行综述，为国内开展应用TED治疗小儿SBS提供参考。

Teduglutide (TED), an analog of intestinotrophic hormone glucagon-like-peptide 2 (GLP-2), may facilitate intestinal nutrient transport, boost intestinal blood flow, promote the proliferation of crypt cells, arrest apoptosis of crypt cells and enhance intestinal barrier function. After dosing TED in adults with short bowel syndrome (SBS), duration/dose of parenteral nutrition (PN) declined. This review summarizes the mechanisms of GLP-2 and TED, as well as the effectiveness and safety of TED for pediatric SBS to provide rationales for domestic researches.