Ganoderma lucidum is a Chinese medicinal fungus with a long history of use in healthcare and disease treatment.G.lucidum spores(GLS)are tiny germ cells released from the mushroom cap during the mature stage of growth.They contain all the genetic active substances of G.lucidum.G.lucidum spore oil(GLSO)is a lipid component extracted from broken-walled Ganoderma spores using supercritical CO2 extraction technology.GLSO contains fatty acids,Ganoderma triterpenes,sterols and other bioactive compounds.Previous studies have demonstrated that GLSO has a wide range of pharmacological properties,including anti-tumor,anti-aging,neuroprotection,immunomodulation,hepatoprotection and modulation of meta-bolic diseases.This review summarizes the research progress of GLSO over the past two decades in terms of its bioactive components,extraction and processing techniques,pharmacological effects and safety evaluation.This provides a solid foundation for further research and application of GLSO.
作者单位：Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine(Institute of Chinese Medicine),Guangdong Pharmaceutical University,Guangzhou 510006,China[1]Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine(Institute of Chinese Medicine),Guangdong Pharmaceutical University,Guangzhou 510006,China;The Second Clinical College of Guangzhou University of Chinese Medicine,Guangzhou Higher Education Mega Center,Guangzhou 510120,China[2]The Second Clinical College of Guangzhou University of Chinese Medicine,Guangzhou Higher Education Mega Center,Guangzhou 510120,China;NMPA Key Laboratory for Rapid Testing Technology of Drugs,Guangdong Institute for Drug Control,Guangzhou 510525,China[3]Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine(Institute of Chinese Medicine),Guangdong Pharmaceutical University,Guangzhou 510006,China;NMPA Key Laboratory for Rapid Testing Technology of Drugs,Guangdong Institute for Drug Control,Guangzhou 510525,China[4]
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