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目的:探讨高压氧联合石杉碱甲在辅助精神分裂症患者无抽搐电休克治疗（MECT）中的应用效果。方法:前瞻性选取2019年3月至2022年4月河南省驻马店市第二人民医院诊治的120例行MECT的精神分裂症患者作为研究对象，采用随机数字表法分为观察组（高压氧联合石杉碱甲治疗）和对照组（石杉碱甲治疗）各60例（由于中途脱落，2组最终分别纳入48例和32例），比较2组患者治疗前后的症状改善情况、短时记忆能力和应激反应相关指标。结果:治疗后，观察组阳性症状得分低于对照组，视觉再认、图片回忆、联想学习、背诵数目得分高于对照组，谷胱甘肽过氧化物酶1（GPX1）、超氧化物歧化酶（SOD）和一氧化氮（NO）水平低于对照组，差异均有统计学意义（ P<0.05）。 结论:高压氧联合石杉碱甲对改善精神分裂症患者MECT后短时记忆有积极影响，同时有助于减轻应激反应和临床症状。

Objective:To explore the effect of hyperbaric oxygen combined with huperzine A in the adjuvant therapy of modified electroconvulsive therapy（MECT）in patients with schizophrenia.Methods:A total of 80 patients with schizophrenia received MECT in Zhumadian Second People's Hospital from March 2019 to April 2022 were prospectively selected as study subjects，and divided into observation group（48 cases，hyperbaric oxygen combined with huperzine A treatment）and control group（32 cases，huperzine A treatment）by the random number table method. Symptom improvement，short-term memory，and stress response related indexes were compared between the two groups before and after treatment.Results:After treatment，the scores of positive symptoms in the observation group were lower than those in the control group，and the scores of visual recognition，picture recall，associative learning，and recitation in short-term memory were higher than those in the control group，and the levels of glutathione peroxidase 1（GPX1），superoxide dismutase（SOD），and nitric oxide（NO）were lower than those in the control group. The differences were statistically significant（ P<0.05）. Conclusion:Hyperbaric oxygen combined with huperzine A has a positive effect on short-term memory in patients with schizophrenia after MECT，and helps to reduce stress response and improve clinical symptoms.