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目的:评估 18F－FDG PET/CT代谢参数与临床相关参数对宫颈鳞状细胞癌(简称鳞癌)患者预后的影响。 方法:回顾性收集青岛大学附属医院2011年5月至2020年12月行基线 18F－FDG PET/CT检查的宫颈鳞癌患者174例[年龄(53.6±11.1)岁]。收集宫颈癌病变的代谢参数[原发肿瘤代谢体积(MTV p)、原发病灶糖酵解总量(TLG p)、全身病灶的MTV之和(MTV total)、全身病灶的TLG之和(TLG total)]及临床参数[国际妇产科联盟(FIGO)分期、肿瘤最大径( Dmax)等]，并通过Cox回归、Kaplan－Meier法分析各参数对于宫颈癌的预后价值。 结果:随访6～120个月，共52例患者疾病进展，占29.9%(52/174)。患者的5年总生存(OS)率、无进展生存(PFS)率、局部控制(LC)率、无远处转移生存(DMFS)率分别为83.3%(145/174)、70.1%(122/174)、75.3%(131/174)、82.8%(144/174)。Cox回归分析示FIGO分期、MTV total为PFS、OS、LC的预测因素[风险比( HR)：1.005～11.605，均 P<0.05]。FIGO分期、TLG total为DMFS的预测因素( HR：1.002～12.258，均 P<0.05)。 结论:MTV total、FIGO分期是预测宫颈鳞癌患者预后的影响因素。

Objective:To estimate the influence of metabolic parameters in 18F-FDG PET/CT and clinically relevant indicators on the prognosis of patients with cervical cancer. Methods:A total of 174 patients with cervical cancer (age (53.6±11.1) years) who underwent baseline 18F-FDG PET/CT examination in the Affiliated Hospital of Qingdao University from May 2011 to December 2020 were retrospectively collected. Metabolic parameters (metabolic tumor volume of primary lesion (MTV p), total lesion glycolysis of primary lesion (TLG p), MTV sum of total lesions (MTV total) in the whole body, TLG sum of total lesions (TLG total)) and clinical parameters (International Federation of Gynecology and Obstetrics (FIGO) stage, tumor maximum diameter ( Dmax), et al) were collected. Cox regression and Kaplan-Meier method were performed to evaluate the prognostic and predictive values of those parameters. Results:The follow-up time was 6-120 months, during which 52 patients (29.9%, 52/174) developed progression. The 5-year overall survival (OS), progression-free survival (PFS), local control (LC) and distant metastasis-free survival (DMFS) rates were 83.3%(145/174), 70.1%(122/174), 75.3%(131/174) and 82.8%(144/174), respectively. Cox regression showed that FIGO stage and MTV total were independent factors for predicting PFS, OS and LC (hazard ratio ( HR): 1.005-11.605, all P<0.05). FIGO stage and TLG total were independent factors for predicting DMFS ( HR: 1.002-12.258, all P<0.05). Conclusion:MTV total and FIGO stage are effective predictors of patients with cervical squamous cell carcinoma.