检索历史 清除

龋病是一种感染性疾病，病原体及其代谢产物的侵入，可激活牙髓牙本质复合体的识别和防御系统。深入理解牙髓牙本质复合体介导的免疫反应，有助于判断疾病进展中牙髓的真实状态，制订合理的临床治疗策略，使其更倾向于组织修复和促进愈合，减少侵入性操作。本文针对牙髓牙本质复合体免疫反应的生理基础、产生的时机与机制、反应性改变、临床干预措施及其意义等进行论述并展望，以期为龋病的临床诊疗提供参考。

Caries is an infectious disease in which the invasion of pathogens and their metabolites can activate the recognition and defense system of the pulpodentinal complex. In-depth understanding of the immune responses mediated by the pulpodentinal complex will help to estimate the real state of the dental pulp during the progression of caries and to take reasonable clinical treatment strategies, which can be more targeted and less invasive. Based on the physiology of the pulpodentinal complex, the present article introduce its immunocompetence and mechanism, reactive changes, clinical intervention and its significance during the caries progression, as to improve diagnostics as well as treatment strategies for caries.