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尽管多个学会和国际工作组已经确定了肌少症的定义,但这些定义有地域性特点.2019-2021年成立的全球肌少症领袖倡议(GLIS)指导委员会旨在建立国际认可的统一的肌少症定义,2022-2023年邀请世界范围内肌少症相关专业学会的代表参加了两个阶段的德尔菲调查.参与者使用在线调查工具(SurveyMonkey)对一系列条目进行同意程度评分.来自7个大洲的29个国家和地区的107名专家完成了德尔菲调查,创建了第1个国际认可的肌少症概念性定义:即肌肉量、肌肉力量和肌肉强度(肌肉力量/肌肉大小)均被认为是肌少症包含的重要内容,而躯体功能受损则被认为是肌少症的结局,而不是组成要素.此次GLIS的国际合作是在全球范围内推进对肌少症的理解和管理的关键一步.在此基础上,将继续探索用于临床和研究中的肌少症可操作性定义.

Various societies and organizations have developed definitions of sarcopenia that are specific to different regions.Currently,there is no international consensus on the definition of sarcopenia.The Global Leadership Initiative in Sarcopenia(GLIS)steering committee,established between 2019 and 2021,aimed to address this issue by creating a global conceptual definition of sarcopenia.From 2022 to 2023,the steering committee conducted a two-phase international Delphi study,inviting experts from major sarcopenia societies and organizations worldwide.Participants used an online survey tool(SurveyMonkey)to rank their agreement with a set of statements.A total of 107 participants from countries across 7 continents/regions completed the Delphi survey.They have developed the first global conceptual definition of sarcopenia,which includes muscle mass,muscle strength and muscle-specific strength(muscle strength/muscle size)as components,and impaired physical performance as an outcome rather than a component of sarcopenia.This international collaborative effort by the GLIS represents a significant advancement in our understanding and management of sarcopenia at a global level.The newly established conceptual definition of sarcopenia will serve as the foundation for developing an operational definition for both clinical and research purposes.