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目的 本研究旨在应用四维自动左心房(简称左房)量化(4D Auto LAQ)技术评价不同年龄段成人左房功能,探讨左房的二维应变与四维应变在不同年龄段之间的差异,为四维左房参数在临床精准应用提供进一步支持.方法 选取409例健康体检志愿者,使用GE公司Vivid E95型超声心动图仪及四维探头,采集二维和四维超声图像,分析二维及四维超声参数在不同年龄段间的差异,并探讨左房储器期应变(LASr)、管道期应变(LAScd)和主动收缩期应变(LASct)等参数与年龄的相关性.结果 409例志愿者(男217例,女192例),青年组(18～45岁)56例,中年组(46～65岁)202例,老年组(＞65岁)151例.常规超声指标显示,青年、中年、老年组左房前后径分别是:(31.70±3.65)mm、(34.02±3.91)mm、(35.2±4.37)mm(P＜0.01),反映心脏结构随年龄增长的适应性变化.二维与四维左房参数在青年、中年、老年组中分别为:LASr(2D)(％):37.48±7.51、30.95±8.23、26.9±7.56(P＜0.01);LA VImax(ml/m2):23.54±5.79、26.33±7.6、28.99±8.15(P＜0.01);LASr(％):31.2±17.07、22.5±8.59、19.49±7.47(P＜0.01).二维与四维左房参数与年龄呈显著正相关,LASr(2D)(％)、LAScd(2D)(％)、LASr(％)、LAScd(％)与年龄的相关性分别为:-0.429、0.580、-0.354、0.298(P＜0.01).结论 4D Auto LAQ技术能够有效评价不同年龄段成人的左房功能,年龄是影响左房参数的重要因素.与其他超声参数相比,二维和四维左房应变参数能在早期体现出差异,适用于早期年龄相关性左房功能异常筛查、评估和监测,特别是在老年人群中有重要的临床推广价值.

Objective This study aimed to assess left atrial function in adults across various age groups using 4-dimensional automated left atrial quantification(4D Auto LAQ)technology.The study also aimed to compare the differences in two-dimensional(2D)and four-dimensional(4D)strains of the left atrium among different age groups,with the goal of enhancing the clinical utility of 4D Auto LAQ.Methods A total of 409 healthy volunteers were recruited for the research.Two-dimensional and four-dimensional images were obtained using a GE Vivid E95 ultrasound system with a 4Vc four-dimensional probe.The study examined variations in 2D and 4D ultrasound parameters across various age groups.Furthermore,the relationship between left atrial reservoir strain(LASr),Left atrial conduit strain(LAScd),left atrial contraction strain(LASct),and age was explored.Results The study involved 409 volunteers,with 217 males and 192 females,who were categorized into three age groups:young(18-45 years,n=56),middle-aged(46-65 years,n=202),and elderly(＞65 years,n=151).Conventional ultrasound measurements indicated changes in left atrial anterior-posterior diameter with age progression:(31.70±3.65)mm for the young group,(34.02±3.91)mm for the middle-aged group,and(35.2±4.37)mm for the elderly group(P＜0.01).The 2D and 4D left atrial parameters across the age groups were as follows:LASr(2D)(％):37.48±7.51,30.95±8.23,26.9±7.56(P＜0.01);LA VImax(ml/m2):23.54±5.79,26.33±7.6,28.99±8.15(P＜0.01);LASr(％):31.2±17.07,22.5±8.59,19.49±7.47(P＜0.01).Both 2D and 4D left atrial parameters exhibited significant associations with age.Specifically,the correlations between LASr(2D)(％),LAScd(2D)(％),LASr(％),LAScd(％),and age were-0.429,0.580,-0.354,0.298,respectively(P＜0.01).Conclusions The 4D Auto LAQ technology is efficient in assessing left atrial function across various age groups,with age playing a significant role in influencing left atrial parameters.When compared to other ultrasound parameters,both 2D and 4D left atrial strain parameters have the ability to detect differences at an early stage,making them suitable for the early screening,evaluation,and monitoring of age-related left atrial dysfunction,especially in the elderly population.