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过敏性紫癜又称为IgA血管炎，肾脏受累即紫癜性肾炎（Henoch-Sch?nlein purpura nephritis，HSPN）是其主要临床表现之一。半乳糖缺陷型IgA1在HSPN发病中发挥了重要作用，其机制与IgA肾病“四重打击假说”相似，IgA1在肾小球系膜区沉积致病，还与炎性反应密切相关，且其致病免疫复合物组成更复杂。因此，异常糖基化IgA1有望成为诊断和预测HSPN发病、判断疾病活动性和预测预后的生物标志物。该文简述了近年来异常糖基化IgA1在HSPN发病机制及临床应用中的研究进展。

Henoch-Sch?nlein purpura is also known as IgA vasculitis. The kidney involvement, namely Henoch-Sch?nlein purpura nephritis (HSPN), is one of IgA vasculitis's main clinical manifestations. Galactose-deficient IgA1 plays an important role in the pathogenesis of HSPN, which not only is similar to the "four-hits hypothesis" of IgA nephropathy, leading to IgA1 deposit in the mesangial region of the kidney, but also is closely related to inflammation with more complicated compositions of its immune complex. Therefore, abnormal glycosylation of IgA1 is expected to be a biomarker for diagnosis and prediction of HSPN pathogenesis, disease activity determination and prognosis prediction. Here, the paper reviews the research progress on the pathogenesis and clinical application of abnormal glycosylation of IgA1 in HSPN.