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中国前瞻性多中心出生队列（Prospective Omics Health Atlas birth cohort，POHA birth cohort）研究于2022年正式启动。本研究联合12个参与单位，旨在建设包含2万个自然妊娠家庭和辅助生殖家庭的高质量多维度队列，对亲代和子代进行长期随访，在重要的时间节点收集对应的生物标本。通过多组学检测和分析，开展母婴全生命周期的多组学大数据研究，以期寻找到母婴疾病新的生物标记物，为母体疾病和新生儿的健康相关的风险预测提供科学依据。

China prospective multicenter birth cohort (Prospective Omics Health Atlas birth cohort, POHA birth cohort) study was officially launched in 2022. This study, in collaboration with 12 participating units, aims to establish a high-quality, multidimensional cohort comprising 20 000 naturally conceived families and assisted reproductive families. The study involves long-term follow-up of parents and offspring, with corresponding biological samples collected at key time points. Through multi-omics testing and analysis, the study aims to conduct multi-omics big data research across the entire maternal and infant life cycle. The goal is to identify new biomarkers for maternal and infant diseases and provide scientific evidence for risk prediction related to maternal diseases and neonatal health.