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消化系统肿瘤是影响人们生活质量的重要因素之一，已经成为全球严重的公共卫生问题，对肿瘤高危人群进行肿瘤标志物的早期筛查并干预是肿瘤预防的关键。卵泡抑素相关蛋白（FRP）是卵泡抑素家族的重要成员，此类蛋白参与了生殖系统、呼吸系统等肿瘤的病理过程，近年来其在消化系统肿瘤的研究中引起了广泛关注，提示FRP可能在消化系统肿瘤的发生发展中发挥重要作用，是临床诊治的潜在标志物。文章综述了与消化系统肿瘤相关的FRP的生物学功能、表达情况及潜在作用机制，以期为消化系统肿瘤的诊断和预防、预后评估和药物研发提供参考。

Tumors of the digestive system are one of the most important factors affecting people′s quality of life and have become a serious public health problem globally.Early screening and intervention of tumor markers in high-risk groups for tumors is the key to tumor prevention. Follistatin-related proteins (FRP) are important members of the follistatin family and such proteins are involved in the pathological process of tumors of the reproductive system and respiratory system, among others. In recent years, FRP has attracted extensive attention in the study of digestive system tumors, suggesting that FRP may play a significant role in the development of digestive system tumors, and is a potential marker for clinical diagnosis and treatment. The article reviews the biological function, expression and potential mechanism of action of FRP associated with digestive system tumors, with a view to providing reference for the diagnosis and prevention of digestive system tumors, prognosis assessment and drug development.