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DNA甲基化是重要的表观遗传学调节机制，在细胞的分化和发育中起重要的作用，其功能的发挥与DNA甲基转移酶-3-α(DNMT3A)密切相关，能够影响基因的表达和干细胞的分化。 DNMT3A基因的突变在急性髓系白血病(AML)中检出率较高，但其突变类型和致病机制尚不明确。对 DNMT3A进行深入的研究，将有助于发现其致病靶点并为AML的精准治疗提供依据。本文就AML中 DNMT3A基因表达研究的进展作一综述。

DNA methylation is an important epigenetic regulatory mechanism which plays a crucial role in cell differentiation and development. Its function is closely related to DNA methyltransferase 3 alpha (DNMT3A), which can affect gene expression and stem cell differentiation. The mutation rate of the DNMT3A gene is relatively high in Acute myeloid leukemia (AML), but its type and pathogenic mechanism are not yet clear. Further research on DNMT3A may help to identify its pathogenic targets and provide a basis for precise treatment of AML. This article has provided a review for the research progress on the expression of the DNMT3A gene in AML.