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Although some traditional animal models for studying schizophrenia have been wildly used,many problems remain in their credibility and validity.We propose that structured animal models with the integration of multiple symptom-inducing factors are be better in simulating the symptoms of schizophrenia and represent the new direction of the future ani-mal-model development.In this article,we review previous studies in this line of research and emphasize the importance of combining the behavior paradigm of the structured top-down attentional modulation of prepulse inhibition with multiple path-ogenic factors related to schizophrenia to establish a new model generation,which will be of great significance in investigating both the pathogenesis and the treatment of schizophrenia.