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OBJECTIVE:To explore the material basis of the difference of efficacy of Dahuang(Radix Et Rhizoma Rhei Palmati)-Taoren(Semen Persicae)(DT)drugs with different proportions.METHODS:Samples of different ratios of Dahuang(Radix et Rhizoma Rhei Palnati,DH)to Taoren(Semen Persicae,TR)(Group A 1∶1,B 2∶3,C 3∶2)were analyzed based on gas chromatography time-of-flight mass spectrometry untargeted metabolomics technique.RESULTS:A total of 240 primary metabolites were detected.Forty-one differential metabolites involved nine differential metabolic pathways,of which four were closely related to the efficacy of DT in the treatment of heat and blood stasis syndrome.These pathways included the biosynthesis of amino acid(phenylalanine tyrosine and tryptophan),flavonoids,unsaturated fatty acids,and the glycolysis/glycogenesis pathway.CONCLUSION:There are significant differences in the efficacy of different ratios of DT drugs,and their optimal ratio for the treatment of heat and blood stasis syndrome should be 1∶1.