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OBJECTIVE:To evaluate the clinical efficacy and safety of Shenzhu Guanxin recipe granules(参术冠心颗粒,SGR)in treating patients with intermediate coronary lesions(ICL),and to investigate the potential mechanism though a transcriptome sequencing approach.METHODS:ICL patients with Qi deficiency and phlegm stasis were adopted and randomly assigned to a case group or a control by random number generator in a 1:1 randomization ratio to evaluate the clinical efficacy.RESULTS:There was no significant difference between the two groups in coronary computed tomography angiography related indexes in the two groups before and after intervention.Through the gene chip expression analysis,it is finally concluded that there are 355 differential mRNAs(190 up-regulated genes and 165 down regulated genes)when compared the SGR group and placebo group.Through protein-protein interaction network analysis of differentially expressed genes,10 hub genes were finally obtained:CACNA2D2,CACNA2D3,DNAJC6,FGF12,SGSM2,CACNA1G,LRP6,KIF25,OXTR,UPB1.CONCLUSIONS:SGR combined with Western Medicine can be safely used to treat ICL patients with Qi deficiency and phlegm stasis.The possible mechanism of action and relevant gene loci and pathway were proposed.