星空体育注册官网|正牌大公司

You Position: Home > Paper

放射治疗对乳腺癌患者免疫功能影响的研究进展

( views:2, downloads:2 )

Author:: No author available

Journal Title:: Journal of BingTuan Medicine

Issue:: 1

DOI:: 10.3969/j.issn.1672-4356.2024.01.027

Key Word:: 放射治疗;乳腺癌;免疫功能;远端效应

Abstract：乳腺癌是一种全身性疾病,传统观点已经认识到乳腺癌对患者的系统性影响,乳腺癌与机体免疫功能的相关关系也已在越来越多的研究中被认识,提示免疫功能在乳腺癌病程中起到了复杂和重要的作用.乳腺癌临床表现的个体化也进一步提示了不同免疫功能状态对乳腺癌肿瘤细胞的发生、发展有密切的关系.乳腺癌的综合治疗中,放射治疗是疗效明确的选择,相当多的基础研究及临床观察,除了证明放射治疗在乳腺癌综合治疗中的地位,也观察到放射治疗对免疫系统的特殊作用和影响,其重要作用已经对治疗效果及预后产生重要影响.根据既往的放射生物学知识,由于对处于细胞周期内的造血细胞等分裂活跃的细胞存在显著的杀伤效果,由此推断放射线对免疫功能特别是细胞免疫具有抑制作用,使免疫系统的功能异常.随着研究的进展,尤其是对不同分割模式和剂量的探索发现,放射治疗可能对乳腺癌患者的先天性免疫系统和适应性免疫系统存在正向作用,即放射治疗可能对乳腺癌患者免疫系统存在调节作用,并可能诱发"远端效应"等有趣的临床现象.结合研究结果,不同的分割模式和最佳剂量对乳腺癌患者的免疫功能影响的对应关系尚需大量研究证实,最佳的放射治疗模式仍需要探索,以提高机体的抗肿瘤作用,发挥放射治疗最佳疗效.本文就放射治疗对乳腺癌患者免疫功能的影响作一简要综述.

Reference

[1]朴春南,刘佳,高刚,等.放射治疗对乳腺癌患者外周血免疫系统相关指标的影响[J].2021,(3).
[2]袁晨曦.不同放射治疗分割模式对乳腺癌患者外周血淋巴细胞及其亚群影响的比较性分析[D].2018.
[3]Liu Rongjun,Xiong Shudao,Zhang Lei,etc.Enhancement of antitumor immunity by low-dose total body irradiationis associated with selectively decreasing the proportion and number of T regulatorycells[J].2010,7(2).
[4]Kawashima N,Dewan MZ,Galloway AE.Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody.[J].2009,15(17).
[5]Ana, Teresa Pinto,Marta, Laranjeiro Pinto,Ana, Patrícia Cardoso,etc.Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities.[J].2016.
[6]Robins HS,Campregher PV,Srivastava SK.Comprehensive assessment of T-cell receptor beta-chain diversity in alphabeta T cells.[J].2009,114(19).
[7]Elizabeth W, Newcomb,Sandra, Demaria,Yevgeniy, Lukyanov,etc.The combination of ionizing radiation and peripheral vaccination produces long-term survival of mice bearing established invasive GL261 gliomas.[J].2006,12.
[8]Laia, Gorchs,Turid, Hellevik,Jack-Ansgar, Bruun,etc.Cancer-associated fibroblasts from lung tumors maintain their immunosuppressive abilities after high-dose irradiation.[J].2015,5.
[9]Vignard,J.,Mirey,G.,Salles,B..Ionizing-radiation induced DNA double-strand breaks: A direct and indirect lighting up[J].2013,108(3).
[10]Inigo,Martinez-Zubiaurre,Anthony J,Chalmers,Turid,Hellevik.Radiation-Induced Transformation of Immunoregulatory Networks in the Tumor Stroma.[J].2018,9.
[11]Kachikwu EL,Iwamoto KS,Liao YP,etc.Radiation enhances regulatory T cell representation.[J].2011,81(4).
[12]Konkel, Joanne E.,Zhang, Dunfang,Zanvit, Peter,etc.Transforming Growth Factor-beta Signaling in Regulatory T Cells Controls T Helper-17 Cells and Tissue-Specific Immune Responses[J].2017,46(4).
[13]Franziska Eckert,Philipp Schaedle,Daniel Zips,etc.Impact of curative radiotherapy on the immune status of patients with localized prostate cancer[J].2018,7(11).
[14]Lanzavecchia, Antonio,Sallusto, Federica.Dynamics of T Lymphocyte Responses: Intermediates, Effectors, and Memory Cells.[J].2000,290(5489).
[15]Zhang N,Bevan MJ.CD8(+) T cells: foot soldiers of the immune system.[J].2011,35(2).
[16]Mackenzie, Karen J.,Carroll, Paula,Martin, Carol-Anne,etc.cGAS surveillance of micronuclei links genome instability to innate immunity[J].2017,548(Aug.24 TN.7668).
[17]Galluzzi Lorenzo,Buqué Aitziber,Kepp Oliver,etc.Immunogenic cell death in cancer and infectious disease[J].2016,17(2).
[18]Leanna J, Standish,Carolyn, Torkelson,Frank A, Hamill,etc.Immune defects in breast cancer patients after radiotherapy.[J].2008,6.
[19]Yan, Mao,Qing, Qu,Yuzi, Zhang,etc.The value of tumor infiltrating lymphocytes (TILs) for predicting response to neoadjuvant chemotherapy in breast cancer: a systematic review and meta-analysis.[J].2014,9.
[20]Silvia C Formenti,Nils-Petter Rudqvist,Encouse Golden,etc.Radiotherapy induces responses of lung cancer to CTLA-4 blockade.[J].2018,24(12).
[21]Jannie,Borst,Tomasz,Ahrends,Nikolina,B?ba?a,etc.CD4<sup>+</sup> T cell help in cancer immunology and immunotherapy.[J].2018.
[22]Klug,F.,Prakash,H.,Huber,P.E.,etc.Low-Dose Irradiation Programs Macrophage Differentiation to an iNOS+/M1 Phenotype that Orchestrates Effective T Cell Immunotherapy[J].2013,24(5).
[23]Kioi M,Vogel H,Schultz.Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice.[J].2010,120(3).
[24]North R. J..Radiation-induced, immunologically mediated regression of an established tumor as an example of successful therapeutic immunomanipulation. Preferential elimination of suppressor T cells allows sustained production of effector T cells[J].1986.
[25]Savage, Talicia,Pandey, Sanjay,Guha, Chandan.Postablation Modulation after Single High-Dose Radiation Therapy Improves Tumor Control via Enhanced Immunomodulation[J].2020,26(4).
[26]Heylmann,D.,R?del,F.,Kindler,T.,etc.Radiation sensitivity of human and murine peripheral blood lymphocytes, stem and progenitor cells[J].2014,1846(1).
[27]Kawai T,Akira S.Signaling to NF-kappaB by Toll-like receptors.[J].2007,13(11).
[28].Effect of surgery and radiotherapy on complete blood count, lymphocyte subsets and inflammatory response in patients with advanced oral cancer[J].2018,18(1).
[29]Mogensen TH.Pathogen recognition and inflammatory signaling in innate immune defenses.[J].2009,22(2).
[30]Bilsky MH,Johnson J,Yamada Y,etc.High-dose, single-fraction image-guided intensity-modulated radiotherapy for metastatic spinal lesions.[J].2008,71(2).
[31]Vanpouille-Box, Claire,Diamond, Julie M.,Pilones, Karsten A.,etc.TGF beta Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity[J].2015,75(11).
[32]Cynthia A, Znati,Maury, Rosenstein,Trevor D, McKee,etc.Irradiation reduces interstitial fluid transport and increases the collagen content in tumors.[J].2003,9.
[33]Greco C,Fuks Z,Rosenzweig K,etc.Predictors of local control after single-dose stereotactic image-guided intensity-modulated radiotherapy for extracranial metastases.[J].2011,79(4).
[34]Levy O,Ezernitchi AV,Halabi A,etc.TCR zeta down-regulation under chronic inflammation is mediated by myeloid suppressor cells differentially distributed between various lymphatic organs.[J].2006,177(7).
[35]Liang Hua,Deng Liufu,Hou Yuzhu,etc.Host STING-dependent MDSC mobilization drives extrinsic radiation resistance[J].2017,8(1).
[36]Sergey V, Kozin,Walid S, Kamoun,Yuhui, Huang,etc.Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation.[J].2010,70.
[37]D E, Hallahan,L, Geng,A J, Cmelak,etc.Targeting drug delivery to radiation-induced neoantigens in tumor microvasculature.[J].2001,74(1-3).
[38]Lee Y,Auh SL,Wang Y.Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment.[J].2009,114(3).
[39]Muroyama, Yuki,Nirschl, Thomas R.,Kochel, Christina M.,etc.Stereotactic Radiotherapy Increases Functionally Suppressive Regulatory T Cells in the Tumor Microenvironment[J].2017,5(11).
[40]Groothuis TA,Hodge JW,Camphausen K,etc.Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy.[J].2006,203(5).
[41]Golden,E.B.,Frances,D.,Pellicciotta,I.,etc.Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death[J].2014,3(4).
[42]Marka R. Crittenden,Talicia Savage,Benjamin Cottam,etc.Expression of Arginase I in Myeloid Cells Limits Control of Residual Disease after Radiation Therapy of Tumors in Mice[J].2014,182(2).
[43]Mazzoni A.,Bronte V.,Visintin A.,etc.Myeloid Suppressor Lines Inhibit T Cell Responses by an NO-Dependent Mechanism[J].2002.
[44]Uematsu S,Akira S.Toll-like receptors and Type I interferons.[J].2007,282(21).