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研究Müller细胞在黄斑疾病发展过程中的作用的最新进展

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Author:: No author available

Journal Title:: Journal of BingTuan Medicine

Issue:: 1

DOI:: 10.3969/j.issn.1672-4356.2024.01.029

Key Word:: Müller细胞;黄斑中心凹;Müller细胞锥;黄斑水肿;黄斑裂孔

Abstract： Müller细胞属于视网膜的放射型胶质细胞,其双极形态的特点使其在保护内部环境的平衡以及保证神经元的完好、稳固以及传递信息等领域起着关键的角色.Müller细胞的神经胶质增生反应在所有种类的视网膜疾病中都被观察到,并且它们还对整个视网膜疾病的生物学过程起着调节作用.经过研究,Müller细胞不仅在形态上呈现出神经干细胞的特性,而且在功能性质上也与之相似.此外,在视网膜遭受损伤时,Müller细胞具备潜能沿视网膜神经细胞的路径进行分化.Müller细胞有能力成为视网膜受损后重建神经元的基础,这将对视网膜疾病的诊断和治疗带来全新的思路.所以,准确了解Müller细胞如何响应病理刺激以及它们所带来的防御与破坏效果,对于探索视网膜受损的原理以及引领疾病的诊断治疗至关重要.这篇文章主要讨论了Müller细胞在黄斑裂孔和黄斑水肿的形成和恢复过程中的影响,目的是为了给视网膜神经的保护提供新的方法.

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