You Position: Home > Paper
朗格汉斯组织细胞增生症1例并文献复习
( views:15, downloads:25 )
- Author:
- No author available
- Journal Title:
- Journal of BingTuan Medicine
- Issue:
- 1
- DOI:
- 10.3969/j.issn.1672-4356.2024.01.037
- Key Word:
- 朗格汉斯组织细胞增生症;病理特征;免疫组化;文献复习
Abstract： 目的:探讨朗格汉斯细胞组织细胞增生症(Langerhans cell histiocytosis,LCH)的临床病理学特点、基因改变、免疫表型以及鉴别诊断.资料与方法:回顾性分析1例LCH患者临床病理学特征、基因检测、免疫表型以及鉴别诊断,并复习相关文献.结果本例患者为女性,年龄35岁,临床病理有LCH特征性的组织学形态,免疫表型:肿瘤细胞S-100、CyclinD1、P53、CD1a阳性,CD68和BRAFV600E阴性,Ki67肿瘤细胞30％表达.结论LCH属于罕见的疾病,具有特征性的组织学形态,S-100、CyclinD1、P53、CD1a、CD68以及BRAFV600E对诊断及鉴别诊断有非常重要的意义.
- [1]孙浩然,李霄,李涛,等.骨原发性朗格汉斯组织细胞增生症中Cyclin D1的表达及临床意义[J].2020,(8).
- [2]叶承祖,陆敏,胡君程.朗格汉斯细胞组织细胞增生症临床病理分析并文献复习[J].2022,29(8).
- [3]Chakraborty,R.,Hampton,O.A.,Shen,X.,etc.Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis[J].2014,124(19).
- [4]Goyal Gaurav,Shah Mithun V.,Hook Christopher C.,etc.Adult disseminated Langerhans cell histiocytosis: incidence, racial disparities and long‐term outcomes[J].2018,182(4).
- [5]Cai Jiaoyang,Huang Xia,Yin Minzhi,etc.A novel fusion gene PLEKHA6‐NTRK3 in langerhans cell histiocytosis[J].2019,144(1).
- [6]Shanmugam, Vignesh,Craig, Jeffrey W.,Hornick, Jason L.,etc.Cyclin D1 Is Expressed in Neoplastic Cells of Langerhans Cell Histiocytosis but Not Reactive Langerhans Cell Proliferations[J].2017,41(10).
- [7]Pina-Oviedo, Sergio,Medeiros, L. Jeffrey,Li, Shaoying,etc.Langerhans cell histiocytosis associated with lymphoma: an incidental finding that is not associated with BRAF or MAP2K1 mutations[J].2017,30(5).
- [8]Chatterjee, Debajyoti,Vishwajeet, Vikarn,Saikia, Uma Nahar,etc.CyclinD1 Is Useful to Differentiate Langerhans Cell Histiocytosis From Reactive Langerhans Cells[J].2019,41(3).
- [9]Brown,N.A.,Furtado,L.V.,Betz,B.L.,etc.High prevalence of somatic MAP2K1 mutations in BRAF V600E-negative Langerhans cell histiocytosis[J].2014,124(10).
- [10]Maliheh, Khoddami,Seyed Alireza, Nadji,Paria, Dehghanian.Herpes Simplex Virus and Langerhans Cell Histiocytosis.[J].2017,12(4).
- [11]Papo Matthias,Cohen-Aubart Fleur,Trefond Ludovic,etc.Systemic Histiocytosis (Langerhans Cell Histiocytosis, Erdheim–Chester Disease, Destombes–Rosai–Dorfman Disease): from Oncogenic Mutations to Inflammatory Disorders[J].2019,21(7).
- [12]Sasaki, Yuya,Guo, Ying,Arakawa, Fumiko,etc.Analysis of the BRAFV600E mutation in 19 cases of Langerhans cell histiocytosis in Japan[J].2017,35(3).
- [13]Hervier,B.,Haroche,J.,Arnaud,L.,etc.Association of both Langerhans cell histiocytosis and Erdheim-Chester disease linked to the BRAFV600E mutation[J].2014,124(7).
- [14]A D H,Brys,S,Vermeersch,R,Forsyth,etc.Central diabetes insipidus: beware of Langerhans cell histiocytosis![J].2018,76(10).
- [15]Abdellatif, Tazi,Constance, de Margerie,Jean Marc, Naccache,etc.The natural history of adult pulmonary Langerhans cell histiocytosis: a prospective multicentre study.[J].2015,10.