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Clinical Evaluation of Determination the Changes on Serum Hcy and MMP-2,TIMP-2 Levels in Patients with Malignant Hydatidiform Mole
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- Author:
- No author available
- Journal Title:
- JOURNAL OF RADIOIMMUNOLOGY
- Issue:
- 6
- DOI:
- 10.3969/j.issn.1008-9810.2013.06.010
- Key Word:
- 恶性葡萄胎;同型半胱氨酸;基质金属蛋白酶-2;金属蛋白酶组织抑制因子
Abstract： 目的:评估了恶性葡萄胎患者化疗前后血清Hcy和MMP-2、TIMP-2水平的变化及临床意义.方法:应用酶免法和放射免疫分析对32例恶性葡萄胎患者进行了化疗前后血清Hcy和MMP-2、TIMP检测,并与35名正常妇女作比较.结果:恶性葡萄胎患者在化疗前血清Hcy和MMP-2、TIMP-2水平均非常显著地高于正常妇女组(P<0.01),化疗后6个月未复发的29例中其水平明显下降或接近正常,而复发的3例,其水平又回升到化疗前水平(P<0.01).结论:检测恶性葡萄胎患者血清Hcy和MMP-2、TIMP-2水平的变化可作为患者诊断和疗效观察的参考.
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