You Position: Home > Paper
The Changes on Serum β-hBD-2, OPN, pro-ADM and NPt Levels in MODS Patients with Post-traumatic Infection
( views:238, downloads:17 )
- Author:
- No author available
- Journal Title:
- JOURNAL OF RADIOIMMUNOLOGY
- Issue:
- 6
- DOI:
- 10.3969/j.issn.1008-9810.2013.06.045
- Key Word:
- 多器官功能障碍综合征;人类β防御素-2;骨桥蛋白;新蝶呤;肾上腺髓质素前体
Abstract： 目的:探讨多器官功能障碍综合征(multiple organ dysfunction syndrome,MODS)患者的炎症感染病理过程中炎性介质水平的变化.方法:血清人类β防御素-2(human β-defensin-2,β-hBD-2)、骨桥蛋白(osteopontin,OPN)和新蝶呤(neopterin,NPt)采用酶联免疫分析法(ELISA)测定,肾上腺髓质素前体(pro-adrenomedullin,pro-ADM)检测采用化学免疫发光法.结果:四项血清标志物测定结果分别显示,对照组和确诊时组β-hBD-2、OPN、pro-ADM、NPt四种血清炎症介质标志水平均显著高于正常人组(P<0.05,P<0.01),出院前组β-hBD-2、OPN水平显著高于正常人组,另两项指标均与正常人组比较无显著性差异(P均>0.05);同时确诊时组与对照组比较β-hBD-2、OPN、pro-ADM三项指标水平也显著升高(P<0.05,P<0.01),NPt水平患者组呈略高,但无统计学意义(P>0.05);出院前组β-hBD-2、OPN、pro-ADM、NPt四种血清炎症介质标志水平均显著低于确诊时组(P<0.05,P<0.01).结论:MODS患者的炎症感染病理过程中炎性介质水平显著升高,其测定对于临床抗感染治疗提供重要价值.
- [1]卢文新,陈鸿昌.420例闭合性腹外伤的诊治分析[J].2006,(3).
- [2]胡晓铭,徐宇,洪波.骨折手术部位感染患者血浆β-防御素-2的检测及临床意义[J].2011,(4).
- [3]胡森.多器官功能障碍综合征概述[J].2008,(12).
- [4]夏庆,曹云,杨毅,等.血浆肾上腺髓质素前体在新生儿感染中的变化及其意义[J].2010,(1).
- [5]胡诗婉,毛毳,张丹,等.人防御素α5、人防御素β2在不孕患者输卵管的表达及意义[J].2010,(3).
- [6]崔巍,李丹阳,王懿娜,等.脓毒症患者血清新喋呤改变及其意义[J].2001,(4).
- [7].首届全国多发伤学术会议纪要[J].1994,(1).
- [8]Mitchell Levy,Mitchell Fink,John Marshall,etc.2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference[J].2003,31(4).
- [9]王今达,王宝恩.多脏器功能失常综合征（MODS）病情分期诊断及严重程度评分标准[J].1995,(6).
- [10]Struck J,Harbarth S,Bergmann A,etc.Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study.[J].2005,9(6).
- [11].American College of Chest Physicians/ Society of Critical Care Medicine Consensus ConferenceDefinitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis[J].1992,20(6).