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Clinical Application of Flow-cytometry in Uterine Cervix Carcinoma and Precancerous Lesion of Uterine Cervix
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- Author:
- No author available
- Journal Title:
- JOURNAL OF RADIOIMMUNOLOGY
- Issue:
- 6
- DOI:
- 10.3969/j.issn.1008-9810.2013.06.046
- Key Word:
- 宫颈肿瘤;宫颈上皮内瘤变;流式细胞术;乳头瘤病毒;人
Abstract： 目的:探讨流式细胞术在宫颈癌及宫颈上皮瘤变的临床应用.方法:采用流式细胞术对61例宫颈癌(33例CINⅡ～Ⅲ、28例CINⅠ和10例正常宫颈组织进行DNA含量分析,并以DNA指数(DI)、异倍体率、增殖指数(PI)作为DNA含量分析参数.结果:①DI值、PI值和异倍体率随着宫颈病变程度的加重呈增高趋势.②异倍体宫颈癌PI值与其二倍体PI值无显著差异;异倍体CINⅡ～ⅢPI值高于其二倍体,具有显著性差异,异倍体CINⅠPI值高于其二倍体,具有极显著性差异;二倍体CINⅡ～ⅢPI值高于正常宫颈组织,具有极显著差异,二倍体CINⅠPI值略高于正常宫颈组织,无显著性差异.③宫颈癌DI值、PI值和异倍体率均随着病理组织分级、临床分期升高而增高,有统计学意义.结论:流式细胞术在辅助宫颈癌前病变确诊、生物学行为预测以及宫颈癌预后判断方面提供重要临床价值.
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