You Position: Home > Paper
Expression and Significance of Vascular Endothelial Growth Factor and Transforming Growth Factor-β1 in Hepatic Fibrosis
( views:197, downloads:60 )
- Author:
- No author available
- Journal Title:
- JOURNAL OF RADIOIMMUNOLOGY
- Issue:
- 6
- DOI:
- 10.3969/j.issn.1008-9810.2013.06.055
- Key Word:
- 肝纤维化;血管内皮生长因子;转化生长因子β1
Abstract： 目的:探讨血管内皮生长因子(VEGF)及转化生长因子β1(TGF-β1)在肝纤维化患者中的表达及其意义.方法:选择66例肝纤维化患者为观察组,另选择100名体检健康者为正常对照组,采用免疫组织化学方法检测两组血清VEGF及TGF-β1浓度.结果:观察组血清VEGF及TGF-β1浓度为(110.87±22.64)ng/L和(15.08±3.27)μg/L,显著高于对照组(15.98±4.75)ng/L和(7.17±1.86)μg /L(t值分别为20.166、11.066、P均＜0.001);观察组S1、S2、S3、及S4期患者血清VEGF分别为(84.25±16.86)、(101.87±26.70)、(118.04±20.75)、(134.65±25.73)ng/L(F=15.689,P<0.05),TGF-β1分别为(10.87±2.64)、(13.06±2.74)、(17.87±3.28)、(22.76±4.75)μg /L(F=12.438,P<0.05);肝纤维化患者血清VEGF与TGF-β1水平呈正相关(r=0.532,P<0.05).结论:血清VEGF与TGF-β1水平与肝纤维化的发生发展密切相关,二者联检可作为诊断及判断病情的血清学指标.
- [1]韦燕飞,彭岳,谢海源,等.基于肝星状细胞分子机制的抗肝纤维化研究进展[J].2009,(17).
- [2]张峰,魏东华,孔德松,等.肝纤维化中星状细胞促血管生成分子机制的研究[J].2011,(9).
- [3]卢秀珍,毕宏生,崔彦.血管内皮生长因子与促血管生成素1对大鼠血管内皮细胞的作用[J].2012,(2).
- [4]宋正己,王吉耀.血管新生与肝纤维化[J].2008,(5).
- [5]李定国,汪保灿.肝内肌成纤维细胞和星状细胞在肝纤维化中的作用[J].2007,(23).
- [6]中华肝脏病学会肝纤维化学组.肝纤维化诊断及疗效评估共识[J].2002,(5).
- [7]曾婕,吴莉莉,郑荣琴,等.实时剪切波弹性成像检测肝脏弹性模量与肝纤维化分期的相关性研究[J].2012,(9).
- [8]Soon Ha, Kwon,Soung Won, Jeong,Jae Young, Jang,etc.Cyclooxygenase-2 and vascular endothelial growth factor in chronic hepatitis, cirrhosis and hepatocellular carcinoma.[J].2012,18(3).
- [9]HIDENARI NAGAI,TAKENORI KANEKAWA,YASUKIYO SUMINO,etc.Serum VEGF as a Tumor Marker in Patients with HCV-related Liver Cirrhosis and Hepatocellular Carcinoma[J].2013,33(3).
- [10]Yang,L.,Inokuchi,S.,Roh,Y.S.,etc.Transforming growth factor-β signaling in hepatocytes promotes hepatic fibrosis and carcinogenesis in mice with hepatocyte-specific deletion of TAK1[J].2013,144(5).
- [11]陈栋良,郭继雄,刘保安,等.血管内皮生长因子、转化生长因子β1、p53在晚期日本血吸虫病肝组织中的表达及意义[J].2009,(6).
- [12]Techung Lee.Stem cell therapy independent of stemness[J].2012,(12).
- [13]Angus,P.W.,Grace,J.A..Hepatopulmonary syndrome: Update on recent advances in pathophysiology, investigation, and treatment[J].2013,28(2).
- [14].病毒性肝炎防治方案[J].2001,(1).
- [15]王宝恩.肝星状细胞与肝纤维化[J].2000,(4).