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Clinical Analysis on Peripheral Blood Th1/Th2 Related Cytokines After Treatment in Patients with Bronchial Asthma
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- Author:
- No author available
- Journal Title:
- JOURNAL OF RADIOIMMUNOLOGY
- Issue:
- 6
- DOI:
- 10.3969/j.issn.1008-9810.2013.06.058
- Key Word:
- 支气管哮喘;白细胞介素-2;白细胞介素-4;白细胞介素-10;γ-干扰素
Abstract： 目的:探讨支气管哮喘患儿治疗前后外周血Th1/Th2相关细胞因子水平的变化及临床意义.方法:应用放射免疫分析和酶联法对31例支气管哮喘患儿进行了外周血中Th1型细胞因子(IL-2、IFN-γ)和Th2型细胞因子IL-4、IL-10浓度,并与35名正常人组作比较.结果:支气管哮喘患儿在治疗前血清IL-2、IFN-γ水平均非常显著地低于正常儿组(P＜0.01),而血清IL-4、IL-10水平又非常显著地高于正常儿组(P＜0.01).经治疗1个月后则与正常儿组比较无显著性差异(P＞0.05).结论:支气管哮喘患儿存在Th1/Th2细胞免疫失衡.Th1免疫功能低下.IFN-γ下调可能是参与哮喘发病机制的重要原因,对哮喘有负向调节作用.哮喘患儿存在Th2细胞免疫功能亢进,以IL-4、IL-10为代表的Th2免疫功能在儿童哮喘的发病中发挥正性促炎作用.
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