Abstract： Objective:To investigate the spatial distribution characteristics of hand, foot, and mouth disease (HFMD) in Beijing from 2020 to 2023, so as to provide insights for regional prevention and control strategies of HFMD.Methods:The information of HFMD case was collected from Chinese Disease Prevention and Control Information System. The cumulative monthly average incidence of each year was analyzed. Spatial auto-correlation analysis and Getis-Ord Gi* analysis were conducted to identify the spatial clustering patterns and distribution trends of HFMD.Results:From 2020 to 2023, a total of 40 371 HFMD cases were reported in Beijing. The highest incidence occurred in 2023 (135.92/100 000). The incidence peaks were typically observed between July and November. The spatial clustering patterns at township and community levels were observed. The hotspots distributed as scattered blocks in 2020 and 2021 and centralized gradually in 2022 and 2023.Conclusions:HFMD in Beijing showed low spatial clustering from 2020 to 2022, higher spatial clustering and centralized hotspots in 2023. Enhanced countermeasures should be implemented in regions of hotspots while areas with lower incidence should remain well prepared for potential resurgences of HFMD.