Abstract： Allergen specific immunotherapy（AIT）is currently the only recognized treatment for the cause of allergic diseases.With the gradual increase in the dose of allergens，AIT can induce the body to establish immune tolerance，prevent the aggravation of allergic symptoms，reduce patients' emergency medication，and block the development of allergic diseases.AIT effectiveness and safety have been affirmed by scholars at home and abroad.Successful AIT can inhibit early and late anaphylaxis，but not all patients respond to AIT.The overall response rate ranges from 50% to 80%，and the course of treatment is long and the cost is high.Therefore，it is particularly important to identify biomarkers that can predict and evaluate the efficacy.This article mainly reviews the research progress on the correlation between the changes of biomarkers（immunoglobulin and cytokines）and the efficacy of AIT，in order to provide reference for pediatricians.