Abstract： Objective To explore the influence of Echinococcus granulosus,(E.granulosus)infection on liver regeneration in hepatectomy model in mice,and to investigate the expression of MyD88/IL-23 in the liver regeneration of E.granulosus-infected mice post hepatectomy and its sig-nificance.Methods A mouse model with 70%hepatectomy following subcutaneous infection of E-.granulosus was established.A total of 18 E.granulosus-infected mice and 18 healthy mice as con-trols were chosen for the surgery.The amount and rate of liver regeneration at different time points post-surgery in mice between the two groups were analyzed.The expression levels of MyD88 and IL-23 in mouse serum at different time points were measured by ELISA.The changes in hepatic function indicators AST and ALT were also monitored.Results Compared to the control mice,the E-.granulosus-infected mice demonstrated decreased liver regeneration amount and regeneration rate post hepatectomy,with significant differences apparent at the time points of 12 hours,1 day,and 2 days post-surgery.In comparison to the control mice,the E.granulosus-infected mice exhibited markedly increased levels of AST and ALT in peripheral blood 1 day post-surgery,and notably in-creased levels of MyD88 and IL-23 2 hours post-surgery.Conclusions E.granulosus infection sig-nificantly decelerates the liver regeneration process following hepatectomy in mice,which may through increasing the levels of MyD88 and IL-23.