Abstract： Objective To construct a prognostic circRNA-miRNA-mRNA ceRNA network in gastric cancer(GC)and explore the diagnostic and therapeutic targets.Methods Differentially expressed circular RNAs(circRNA),related microRNAs(miRNA)and mRNAs in GC were ob-tained from GEO and TCGA databases.Cytoscape was utilized to construct the circRNA-miRNA-mR-NA ceRNA network,to understand the biological functions of differentially expressed mRNAs and i-dentifying the hub genes.Kaplan-Meier survival analysis was used to verify the prognostic val-ues.Results The ceRNA network was consisted of 2 circRNAs,5 miRNAs and 349 mRNAs that were differentially expressed.Functional enrichment analysis revealed that mRNAs were significantly enriched in terms and pathways like"muscle system process","metal ion transmembrane trans-porter activity","synaptic membrane"and"calcium signaling pathway".A PPI network contai-ning 125 nodes and 165 edges was constructed and 10 hub genes were identified.Survival analysis implied that low ADAR1D or PTGFR expression levels might lead to poor prognosis of GC pa-tients.Conclusion The circRNA-miRNA-mRNA ceRNA network involved in prognosis of GC is successfully constructed.Two axes,the hsa_circ_0001190/hsa-miR-7-5p/ADRA1D and the hsa_circ_0036287/hsa-miR-3127-5p/PTGFR,are identified with potential prognostic values in GC,providing a new target for diagnosis andtreatment of GC.