Abstract： In recent years,the application of lipidomics in lung cancer research has received increasing attention,providing new perspectives on understanding the pathogenesis and therapeutic strategies of lung cancer.With technological advances,lipidomics will play a more critical role in lung cancer research and provide more specific biomarkers and pharmacodynamic evaluation tools for early diagnosis,condition monitoring,and personalized treatment of lung cancer.This review dis-cusses the critical roles of core technologies like mass spectrometry and bioinformatics in lung cancer research.It also emphasizes the importance of serum and tissue-based lipidomics analysis in explo-ring specific biomarkers and differences between subtypes of lung cancer.Novel lipidomics strategies provide new directions for elucidating lung cancer pathogenesis and therapeutic strategy selection.