Abstract： Objective To explore the mechanism of bifendate derivatives in improving diabetic nephropathy and renal func-tion.Methods Fifty SPF grade 6-8 week old C57BL/6J mice,of which,15 were in the control group and 35 in the diabetic ne-phropathy model group.The mice in the control group were divided into a normal control group(n=7)and a control administration group(n=8),and the mice in the diabetic nephropathy model group were divided into model group,low-dose administration group,medium-dose administration group,high-dose administration group,and resveratrol-positive drug group(each had 7 mice).Samples were taken after 8 weeks of drug administration.The basic parameters and renal function related indexes of mice were detected,glyco-gen staining experiments detected the accumulation of glycogen in renal tissues,Sirius red staining detected the fibrosis of renal tissues,and proteomic analysis was performed by Q-Exactive mass spectrometer.The differences of the indexes between the comparison groups were analyzed.Results Different doses of bifendate derivatives significantly reduced fasting blood glucose in mice(P<0.05).Medi-um and high doses of bifendate derivatives significantly reduced serum urea nitrogen and creatinine levels in mice(P<0.05).Glyco-gen staining experiments suggested that different doses of benzene bilipid derivatives could alleviate the accumulation of glycogen in the kidneys of mice.Sirius red staining experiments showed that different doses of benzene bisabolol derivatives could alleviate the fibrotic lesions in the kidneys of mice.A total of 5032 proteins were identified by proteomic analysis,and 104 differentially expressed proteins were screened.Conclusion Bifendate derivatives have the potential to be potential drugs for the treatment of diabetes mellitus and re-lated complications such as diabetic nephropathy.