Abstract： According to the training objectives of Traditional Chinese Medicine and Chinese Materia Medica specialty of Capital Medical University and the curriculum objectives of Chinese Materia Medica,closely contact the basic knowledge in the early stage and clinical practice in the late stage,integrate the curriculum content of Chinese Materia Medica,carry out the teaching practice of Chinese Materia Medica with the integration of Chinese Materia Medica and prescription training in combination with teaching meth-ods such as problem-based learning medical record discussion and practice,prescription training and classical materia medica learning after class,and explain the teaching reform effect of Chinese Materia Medica based on the concept of"effective teaching"with class-room evaluation.The results suggest that the curriculum reform of Chinese Materia Medica combined with principle-method-recipe-me-dicinal is helpful to improve students'independent learning ability,active participation enthusiasm and in-depth thinking in classroom and application ability of knowledge,and lays a good foundation for the study of later pharmaceutics and other courses.