Abstract： Objective Exploring the value of total parathyroidectomy combined with forearm autotransplantation in the treatment of triple hyperparathyroidism.Method 144 patients with triple essential hyperparathyroidism were randomLy divided into a control group and a study group,with 72 cases in each group.The control group underwent total parathyroidectomy for treatment,while the study group underwent forearm autologous transplantation on the basis of the control group.The biochemical indicators,quality of life,HGB,ALB levels,symptom scores,and clinical efficacy of the two groups of patients were compared.Result After treatment,the patients in the study had lower levels of iPTH,Ca,P,Mg,bone pain VAS,pruritus VAS and sleep SRSS than the control group(P<0.05).Af-ter treatment,the patients in the study had higher levels of ALP,quality of life and treatment efficacy than the control group(P<0.05).Conclusion In patients with triple hyperparathyroidism,the combination of total parathyroidectomy and forearm autograft showed good clinical efficacy,which not only significantly improved the patients'biochemical indicators,but also their quality of life.