Abstract： Objective To observe the clinical study of platelet-rich plasma(PRP)for the treatment of lower extremity atherosclerotic occlusive disease stage Ⅲ.Methods 44 patients with lower extremity atherosclerotic occlusive disease who met the inclusion criteria were selected and randomly divided into two groups of 27 cases each.The control group was treat-ed with intravenous Extract of Ginkgo Biloba Leaves injection and Papaverine hydrochloride for injection,and the treatment group was treated with PRP based on the control group.Both groups were treated for 2 weeks,and the clinical efficacy was evaluated by observing the wound healing rate,serum C-reactive protein(CRP)and fibrinogen(FIB)changes before and after treatment.Results The wound healing rate was higher in the treatment group than in the control group(P<0.05).The reduc-tion of CRP level and FIB level before and after treatment was significantly higher in the treatment group than in the con-trol group(P<0.05).Conclusion Compared with simple debridement,platelet-rich plasma(PRP)used for the treatment of lower limb atherosclerotic occlusive disease stage Ⅲ can improve the wound healing rate,reduce the inflammatory response,and lower fibrinogen,which has good efficacy in clinical practice.