Abstract： Objective Exploring the effect of butorphanol on catheter-related bladder discomfort(CRBD)after transurethral resection of bladder tumor(TURBT)in males.Methods 68 male patients aged≥20y and≤80 years old who underwent TURBT under selective general anesthesia were selected,with ASA grades I to Ⅲ and surgery time ranging from 30 minutes to 120 minutes.Using a random number table generated by online randomization software,patients were divided into two groups:a butorphanol group(Group B)of 34 cases and a control group(Group C)of 34 cases.Group C received anes-thesia induction with sufentanil and physiological saline,while Group B received anesthesia induction with sufentanil and bu-torphanol at a dose of 0.02 mg/kg.Record and compare:①Record the number and degree of CRBD occurrences immediately after extubation(T0),1 hour after surgery(T1),2 hours after surgery(T2),and 6 hours after surgery(T3)in two groups of pa-tients;②Record the dosage of tramadol and sufentanil for two groups of patients;Record the duration of stay in the Postanesthesia care unit(PACU)after anesthesia for two groups of patients;③Record the sedation levels and incidence of dizziness,nausea,and vomiting in two groups of patients.Results The number and severity of CRBD occurrence in Group B patients at T0,T1,T2,and T3 were lower than those in Group C,and the difference was statistically significant(P<0.05).The amount of tramadol used for salvage treatment in Group B patients with moderate to severe CRBD was significantly lower than that in Group C,and the difference was statistically significant(P<0.01).The duration of stay in PACU in Group B was shorter than that in Group C,and the difference was statistically significant(P<0.05).There was no statistically significant dif-ference in the amount of sufentanil used for pain relief,the level of sedation within the PACU,and the occurrence of adverse reactions such as dizziness,nausea,and vomiting between the two groups of patients(P>0.05).Conclusion Butorphanol can significantly reduce the incidence and severity of CRBD after TBRBT surgery,and there are no significant adverse reactions.It can be safely and effectively used to alleviate CRBD.