Abstract： Objective To study the effects of dialectical behavior therapy on cognitive emotion,mental resilience and immune function in patients with mental disorders after heart transplantation.Methods 87 patients with mental disorders after heart transplantation in our hospital were randomly assigned,43 cases in the control group were given routine intervention,and 44 cases in the observation group were added dialectical behavior therapy.2 weeks later,cognitive emotion,mental re-silience,immune function status and quality of life of patients in the two groups were compared.Results After intervention,the negative emotion regulation strategy score of the observation group was lower than that of the control group,and the pos-itive emotion regulation strategy score was higher than that of the control group(P<0.05).After intervention,the score of CD-RISC in observation group was higher than that in control group(P<0.05);After intervention,CD4+,CD8+,CD4+/CD8+levels of T lymphocyte subsets(CD)in observation group were higher than those in control group,and CD8+levels were lower than those in control group(P<0.05).After intervention,the scores of cognitive function,psychological function and physical function in observation group were higher than those in control group(P<0.05).Conclusion Dialectical behavior therapy can effective-ly improve the cognitive emotion and mental resilience of patients with mental disorders after heart transplantation,which is conducive to enhancing immune function and improving quality of life.