Abstract： Objective To analyze the effects of acupuncture and moxibustion combined with musical psychological re-laxation on depression and related somatic symptoms in adolescents.Methods The data of 106 adolescents with depression were retrospectively analyzed,and divided into control group(receiving music psychological relaxation therapy)and observation group(receiving music psychological relaxation therapy+acupuncture therapy)according to different treatment plans,with 53 cases in each group.The clinical efficacy,Hamilton Depression Scale(HAMD-17),Depression and Somatization Symptom Scale(DSSS-22),disease-related factors[NT-3,5-hydroxytryptamine(5-HT),nerve growth factor(NGF)]and adverse reactions were compared between the two groups.Results The total effective rate of observation group was 90.57%(48/53)higher than that of control group 75.47%(40/53)(P<0.05).Compared with control group,HAMD-17 score in observation group was lower after treatment(P<0.05).Compared with before treatment,the somatization score,depression score and DSSS-22 total score of obser-vation group were significantly decreased after treatment(P<0.05).Compared with before treatment,NGF and NT-3 decreased and 5-HT increased in both groups,and the observation group was more significant(P<0.05).Conclusion Music psychologi-cal relaxation combined with acupuncture in the treatment of adolescent depression can regulate the secretion of neurotrans-mitter,reduce the degree of depression,relieve physical symptoms,and have a significant effect and high safety.