Abstract： Objective:To investigate the effects of aerobic exercise training and high-intensity interval training on depression-like behavior and neuropeptide-related genes expression in male mice.Methods:18 mice were randomly divided into control group,constant speed exercise group and high-intensity intermittent exercise group,with 6 mice in each group.Except for mice in the control group,the remaining mice exercised continuously for 8 weeks.After exercise intervention,the immobility time of mice was detected by forced swimming test,and the expression of neuropeptide-related genes in different tissues of the brain(prefrontal cortex,striatum,hippocampus,hypothalamus)were detected by reverse transcription and fluorescence quantitative PCR,including Bdnf,Ghrelin,Npy,Agrp,Cart,Pomc,Crh,Apelin and Mch.Results:Compared with the control group,the immobility time of mice in both exercise groups was decreased(P＜0.05),and the immobility time of mice in high-intensity intermittent exercise group decreased stronger.The expression of Apelin mRNA in hypothalamus of mice in constant speed exercise group was significantly increased(P＜0.01).For high-intensity intermittent exercise group,the Apelin mRNA was significantly decreased(P＜0.05)in striatum,and the mRNA level of Crh(P＜0.05)and Cart(P＜0.01)were significantly decreased in hypothalamus,compared with control group.Conclusion:Both constant speed exercise training and high-intensity interval training could alleviate depression-like behavior in mice,and the high-intensity interval training is better.Both types of exercise influenced the mRNA level of Apelin in the striatum and hypothalamus in mice,and high-intensity interval training reduced the Crh and Cart genes expression in the hypothalamus.