Abstract： Sanguisorba officinalis L.,a traditional Chinese medicine,has the efficacy of cooling blood to stop bleeding,as well as detoxifying and healing sores.The pharmacological mechanism of Sanguisorba officinalis L.has been extensively studied,such as hemostasis and clotting,anti-oxidation,anti-allergy,anti-inflammatory,antibacterial,anti-tumor,renal protection and elevating leukocytes etc.The hemostasis and clotting mechanism is through acting on thrombin,and promoting megakaryocyte differ-entiation and thrombocytopoiesis.The anti-oxidation mechanism is upregulating antioxidant enzyme expression and scavenging oxygen free radicals.The anti-allergic mechanism is inhibiting the production and release of β-hexosaminidase and IL-4,or promoting the expression and activation of heme oxygenase-1.The anti-inflammatory mechanism is related to macrophage polarization,aggregation and migration,lipid metabolism,improvement of intestinal flora imbalance,STAT-1 and ERK activation,autophagy,NF-κB/NLRP3,TLR4/NF-κB,PI3K/Akt/NF-κB/STAT3 signaling pathway and so on.The antibacterial mechanism is destroying the structure of cell wall,cell membrane,and internal microstructure,interfering with the synthesis of total bacterial protein,reducing cell membrane fluidity,changing the expression of metabolic pathway etc.related genes,or inhibiting the expression of penicillin binding protein 2a and gene mecA.The anti-tumor mechanism is related to VEGF/PI3K/Akt/mTOR,EGFR/MAPK,EGFR/PI3K/Akt/NF-κB,HIF-1,MAPK,Ras/MEK/ERK,Wnt,autophagy and other signaling pathways,and lipid phosphatase activity.The mechanism of renal protection is anti-oxidation,anti-inflammation,anti-lipid peroxidation,and inhibiting proliferation of renal tubular epithelial cells.The mechanism of elevating leukocytes is related to autophagy,hematopoietic system related pathways and related genes,hematopoietic growth factor expression,glucose metabolism,amino acid and nucleotide metabolism.It is clinically used for hemorrhage such as gastrointestinal bleeding,allergic purpura,acute eczema,burns,acne,pressure ulcer,acute and chronic glomerulonephritis.Diyu Shengbai Pian is often used for leukopenia,and has definite clinical effect,which shows that modern science and technology promotes clinical application of Sanguisorba officinalis L.This paper reviewed the pharmacological mechanism of Sanguisorba officinalis L.,which provided references for the research and clinical application of Sanguisorba officinalis L.