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Correlation study of serum osteopontin on short-term outcome in acute ischemic stroke patients treated with intravenous recombinant tissue plasminogen activator
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- Author:
- No author available
- Journal Title:
- Clinical Laboratory Journal (Electronic Edition)
- Issue:
- 3
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- No doi available
- Key Word:
- 重组组织型纤溶酶原激活剂;骨桥蛋白;急性缺血性脑卒中;危险因素;预后
Abstract： 目的 分析经重组组织型纤溶酶原激活剂(rt-PA)治疗后的急性缺血性脑卒中(AIS)患者血清骨桥蛋白水平与神经功能改善和预后的关系.方法 选取2016-01-2019-01复旦大学附属金山医院收治的85例AIS患者,根据rt-PA治疗7 d后NIHSS评分较溶栓前的差值分为神经功能改善良好组(ΔNIHSS≥4分)和神经功能改善不良组(ΔNIHSS<4分),比较两组基本信息、血液生化指标和入院时NIHSS评分等.对单因素分析筛选出来可能影响患者早期神经功能改善的因素进一步行Logistic回归分析,分析血清骨桥蛋白水平与预后不良的关系.结果 多因素Logistic回归分析显示年龄较大、NIHSS评分较高、低密度脂蛋白高和骨桥蛋白水平高是影响神经功能改善的危险因素(P<0.05).治疗90 d后采用改良Rankin评分量表对患者情况分别评定.其中85例患者中,预后不良者为14例,预后良好者71例,后者的骨桥蛋白显著低于前者,差异有统计学意义(P<0.001).结论 血清骨桥蛋白水平可能可以作为预测AIS患者静脉溶栓治疗预后的一个重要参考指标.
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