Abstract： Objective To investigate the genotypes of human papillomavirus(HPV)infection in male patients with condyloma acuminatum(CA)and to develop a model for predicting recur-rence risk.Methods Wart samples were collected from 724 CA patients at Jiaozhou Branch of Shanghai East Hospital,Tongji University from January 2021 to June 2023.Human papillomavirus DNA was extracted and genomic DNA was genotyped.Multivariate logistic regression analysis was used to analyze the risk factors for recurrence within 6 months after being cured with physiothera-py,and a prediction model for recurrence risk was developed.Receiver operating characteristic(ROC)curves was used to verify the prediction value of the prediction model.Results Among 724 CA patients,the main genotypes were HPV 6,11,16,and 42.Multivariate logistic regres-sion analysis showed that a disease course of≥6 months,high-risk HPV infection,multiple HPV infections,and the number of warts ≥ 5 were independent risk factors for recurrence(P＜0.05),while using condom was a protective factor for recurrence in CA patients(P=0.010).Multiple factor analysis was used to construct recurrence predictive model.The validation results of the ROC curve showed that when logit(P)＞13.00,the sensitivity and specificity were 71.39％and 83.01％,respectively,and the area under the curve(AUC)was 0.863.Conclusions The main genotypes of HPV infection are HPV 6,11,16,and 42 in male CA patients.The prediction model for recurrence risk factors has high predictive value for predicting recurrence of CA.