Abstract： Objective To evaluate the effect of Qihong Tongluo Prescription(芪红通络方)combined with Tuina on preventing venous thrombosis of lower extremity after total knee arthroplasty(TKA).Methods A total of 96 patients who received elective TKA from December 2021 to 20231 were selected as the study objects and were divided into control group and observation group according to random number table method.After operation,all patients were given anti-infection,analgesia,nutritional support and other conventional treatment.The control group was given Tuina at the same time,and the observation group was also given Qihong Tongluo Prescription on the basis of the control group.The coagulation function indexes[thrombin time(TT),activated partial thrombin time(APTT),fibrinogen(FIB),D-dimer(D-D)],hemorheology indexes[whole blood high shear viscosity,plasma viscosity,hematocrit]and inflammatory factors[interleukin-6(IL-6),hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)]were compared between the two groups.The patients were followed up to 3 months after sur-gery,the functional recovery of knee joint was compared between the two groups,and the occurrence of lower limb venous throm-bosis was recorded between the two groups.Results There were significant differences in the main effects of TT,APTT,FIB or D-D between two groups and among different time points(P＜0.05),and there was interaction between two groups and among differ-ent time points(P＜0.05).After surgery,the values of TT and APTT increased gradually,while the levels of FIB and D-D de-creased gradually.And the values of TT and APTT in the observation group were longer than those in the control group 7 and 14 days after surgery(P＜0.05),and the levels of FIB and D-D were lower than those in the control group(P＜0.05).There were significant differences in the main effects of whole blood high tangential viscosity,plasma viscosity or hematocrit between two groups and among different time points(P＜0.05),and there was interaction between two groups and among different time points(P＜0.05).The levels of whole blood high tangential viscosity,plasma viscosity and hematocrit of the two groups were decreased gradually after surgery,and the observation group had lower mean whole blood high tangential viscosity,plasma viscosity and hydrohematocrit 14 days after surgery than the control group(P＜0.05).The main effects of IL-6,hs-CRP and TNF-α be-tween two groups and among different time points were statistically significant(P＜0.05),and there was interaction between two groups and among different time points(P＜0.05).The levels of IL-6,hs-CRP and TNF-α in both groups were decreased af-ter surgery,and the levels of IL-6,hs-CRP and TNF-α in the observation group were lower than those in the control group 7 and 14 days after surgery(P＜0.05).Follow-up showed that the excellent and good rate of knee function in the observation group(89.58％,43/48)was higher than that in the control group(70.83％,34/48),and the incidence of lower limb venous thrombosis(2.08％,1/48)was lower than that in the control group(14.58％,7/48),and the differences were statistically signifi-cant(P＜0.05).Conclusion Qihong Tongluo Prescription combined with Tuina has more obvious anti-coagulation,thrombolytic and anti-inflammatory effects,which can effectively prevent the formation of lower limb vein thrombosis after TKA,and is worthy of clinical application.