Abstract： Objective To explore the application effect of the method of invigorating Qi and dredging collateral,invigorating spleen and tonifying kidney combined with acupoint application in patients with chronic obstructive pulmonary disease(COPD)at stable stage.Methods A total of 180 patients with COPD in stable stage who were treated in Zhangjiakou Hospital of Traditional Chinese Medicine in Hebei Province from January 2020 to December 2021 were divided into the group A,the group B and the group C(60 cases)by random number table method,60 patients in each group.The three groups were treated with conventional western medicine.The group A was treated with acupoint application,the group B was treated with Yiqi Tongluo,Jianpi Bushen Recipe(益气通络健脾补肾方)and the Group C was treated with the method of invigorating Qi and dredging collateral,invigor-ating spleen and tonifying kidney combined with acupoint application.The three groups were treated for 9 months.The clinical effects after 9 months of treatment,including 6 min walking distance(6MWD),fatigue degree,quality of life,dyspnea index,blood gas index and inflammatory factors before and after 9 months of treatment between two groups were compared.Results After 9 months of treatment,the rate of total effective of the group C was 88.33％(53/60),higher than 55.00％(33/60)and 73.00％(44/60)of the group A and B,and that of the group B was higher than that of the group A(P＜0.05).Compared with that before treatment,after 9 months of treatment,the 6 MWD of the three groups was prolonged,and the 6 MWD of the group C was longer than that of the group A and B,and the 6 MWD of the group B was longer than that of the group A.The scores of fatigue assess-ment scale(Borg),COPD patient assessment test(CAT)and modified British medical research council(mMRC),arterial partial blood pressure of carbon dioxide(PaCO2),the levels of serum interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)in three groups decreased,and the indexes in the group C were lower than those in the group A and B,and those in the group B were lower than those in the group A.The values of blood oxygen saturation(SpO2)and arterial partial oxygen pressure(PaO2)increased in the three groups,and the values of the group C were higher than those of the group A and B,and the value of the group B was higher than that of the group A(P＜0.05).There was no significant difference in potential of hydrogen(pH)before and after treatment and among the three groups(P＞0.05).Conclusion The method of invigorating Qi and dredging collateral,invigorating spleen and tonifying kidney combined with acupoint application could effectively relieve the dysp-nea symptoms of patients with COPD in stable stage,reduce the degree of fatigue and inflammatory reaction,improve the blood gas indicators,the walking ability and quality of life of patients,and then improve the treatment effect.