Abstract： Objective To investigate the clinical effect of Deng's Tongfeng Prescription(邓氏痛风方)combined with external application of Ping'an Powder(平安散)in the treatment of acute gouty arthritis.Methods A hundred patients with acute gouty ar-thritis admitted to the hospital from June 2020 to June 2022 were divided into the observation group and the control group,with 50 cases in each group.The control group was given conventional oral treatment of Western medicine.On the basis of the treatment plan of the control group,the observation group was combined with internal administration of Deng's Tongfeng Prescription and ex-ternal application of Ping'an Powder,and the treatment time of 1 week was given to both groups.Clinical efficacy,main symptom scores,Likert index score,serum levels of interleukin-1 β(IL-1β),red blood cell sedimentation rate(ESR),cyclooxygenase-2(COX-2)and matrix metalloproteinase-9(MMP9)and laboratory indexes before and after treatment and the safety during treat-ment were uniformly compared and analyzed in the observation group and the control group.Results After treatment,the total ef-fective rate of the observation group was 98.00％(49/50),which was higher than that of control group(86.00％,43/50).After treatment,the levels of joint tenderness,joint pain,joint swelling,joint restriction symptom scores,Likert index scores,serum levels of IL-1 β,ESR,COX-2,MMP9,xanthine oxidase(XOD),blood uric acid(BUA)and creatinine(Cr)in two groups showed a de-creasing trend compared with those before treatment,and the observation group had a lower level than the control group(P＜0.05),indicating a significant difference in the calculated data.Conclusion Internal administration of Deng's Tongfeng Prescrip-tion combined with external application of Ping'an powder has significant effect in the treatment of acute gouty arthritis,which can improve the syndrome and joint function of patients,and help to reduce the level of uric acid and inflammatory damage of the body,with high overall safety.