Abstract： Objective To explore the effects of Huangqi Jianzhong Decoction(黄芪建中汤)combined with moxibustion on clinical symptoms,inflammatory response and gastrointestinal hormones in patients with diarrheal irritable bowel syndrome(IBS-D).Methods A total of 80 IBS-D patients admitted to the hospital between January 2020 and October 2022 were selected and divided into observation group(40 cases)and control group(40 cases)by random number table method.All patients were treated with conventional western medicine.The control group was given moxibustion,and the observation group was treated with Huangqi Jianzhong Decoction.The therapeutic efficacy of the two groups was compared.Pre-and post-treatment inflammatory markers[soluble interleukin-2 receptor(SIL2R),tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β)]and serum concen-trations of gastrointestinal hormone indexes[gastrin(GAS),motilin(MTL),somatostatin(SS)].At the same time,the IBS quality of life questionnaire(IBS-QOL)and Hamilton depression scale(HAMD)were used to evaluate the mental state and changes in quality of life of all patients.Results The total effective rate of the observation group was higher than that of the control group(P＜0.05).After treatment,the levels of serum SIL-2R,L-1β,TNF-α and SS in the observation group were lower than those in the control group(P＜0.05),while the concentrations of MTL and GAS were higher than those in the control group(P＜0.05).After treatment,HAMD score of the observation group was lower than that of the control group(P＜0.05)and the IBS-QPL score was higher than that of the control group(P＜0.05).Conclusion Huangqi Jianzhong Decoction combined with moxibustion can effectively improve the clinical symptoms of IBS-D patients,improve the level of inflammation and gastrointestinal function,re-lieve the adverse mood and improve the quality of life of patients.