Abstract： Objective To investigate the effect of Qinggan Xiehuo Chushi Recipe(清肝泻火除湿方)combined with cooling and purging acupuncture in treating dry eye of heat stagnation in liver meridian type.Methods Ninety-five cases of dry eye of heat stagnation in liver meridian type were divided into control group(47 cases treated with sodium hyaluronate eye drops)and study group(48 cases treated with Qinggan Xiehuo Chushi Formula+cooling and purging acupuncture+sodium hyaluronate eye drops)according to different treatment methods.The TCM syndrome scores,corneal fluorescent pigment staining(FLS)score,tear film rupture time(BUT),basic tear secretion volume(SIt)and the levels of inflammatory factors in tears were compared between the two groups.The incidence of adverse reactions in the treatment period of the two groups was counted,and the curative effect of TCM syndrome of the two groups was compared.Results After treatment,the scores and total scores of TCM syndromes in the stud-y group were lower(P＜0.05).After 4 weeks of treatment,FLS score in the study group was lower than that in the control group[(2.16±0.73)points vs(4.37±0.92)points](t=12.984,P＜0.05).The values of BUT[(10.47±1.92)s vs(7.84±1.63)s]and SIt[(8.14±2.06)mm vs(6.53±1.94)mm]in the control group were higher than those in the control group(t=7.190,3.920,P＜0.05).After 4 weeks of treatment,the levels of IL-6[(1.02±0.13)pg/L],IL-1β[(0.67±0.12)pg/L]and TNF-α[(0.16±0.04)pg/L]in the study group were lower than those[(1.36±0.15)pg/L,(1.14±0.19)pg/L,(0.27±0.09)pg/L]in the control group(t=11.814,14.447,7.725,P＜0.05).The incidence of adverse reactions in the two groups was similar during treatment(x2=0.667,P=0.414).The total effective rate of TCM syndrome in the treatment group[95.83％(46/48)]was higher than that in the control group[78.72％(37/47)](x2=6.299,P=0.012).Conclusion Qinggan Xiehuo Chushi Recipe combined with cooling and purging acupuncture can improve the clinical symptoms and the ocular surface func-tion,reduce the levels of inflammatory factors in tears,and improve the efficacy of TCM syndromes,which is safe and reliable.