Abstract： Objective The aim of this study was to explore the effects of Danggui Sini Decoction(当归四逆汤)combined with Simiao Pill(四妙丸)on scores of TCM syndromes and Wnt/β-catenin signaling pathways in diabetic nephropathy(DN).Meth-ods A total of 124 patients with DN in the hospital were enrolled and randomly divided into control group and observation group,62 cases in each group.The control group was treated with routine western medicine,while the observation group was additionally treated with Danggui Sini Decoction and Simiao Pill on basis of control group between January 2021 and October 2023.All were treated for 3 months.The curative effect,the scores of clinical symptoms,blood glucose and lipid,renal function,inflammatory and oxidative stress indexes,the expressions of peripheral blood Wnt/β-catenin signaling pathways and occurrence of adverse reac-tions were compared between the two groups.Results The response rate of treatment was higher in the observation group than that in the control group(96.77％vs 85.48％,P＜0.05).After treatment,the scores of TCM syndromes were lower in the observa-tion group than those in the control group(P＜0.05),the levels of fasting blood glucose(FBG),glycosylated hemoglobin(HbAlC),low-density lipoprotein cholesterol(LDL-C)and triglyceride(TG)were lower in the observation group(P＜0.05),the levels of serum cystatin(Cys-C),urinary microalbumin(ALB)and β2 microglobulin(β2-MG)and urinary albumin excre-tion rate(UAER)were also lower in the observation group(P＜0.05).After treatment,the levels of serum tumor necrosis factorα(TNF-α),malondialdehyde(MDA)and interleukin-6(IL-6)were lower in the observation group than those in the control group,while the level of superoxide dismutase(SOD)was higher in the observation group(P＜0.05).After treatment,mRNA levels of peripheral blood Wnt,Tcf-4 and β-catenin were lower in the observation group than those in the control group(P＜0.05).The difference in the incidence of adverse reactions between the two groups was not statistically significant(P＞0.05).Conclusion Danggui Sini Decoction combined with Simiao Pill is beneficial to improve clinical symptoms in DN patients,effective-ly regulate glucose and lipid metabolism,relieve inflammatory and oxidative stress response,regulate Wnt/β-catenin signaling pathways,and thus improve renal function,which has significant curative effect and high safety.