Abstract： The incidence of lung diseases is increasing rolling year,posing a serious threat to public health.As the significant place for gas exchange in lung,the lung air-blood barrier plays an important role in maintaining lung homeostasis.The lung air-blood barrier is mainly composed of alveolar epithelium and capillary endothelium.The function of lung air-blood barrier is ex-tremely familiar to the physiological function of lung,which is in charge of Qi and respiration.The lung air-blood barrier is in-volved in the regulation of Qi,blood and body fluid of lung,and is closely related to the occurrence and development of a variety of lung diseases.Based on the understanding of traditional Chinese and Western medicine to the lung air-blood barrier and lung diseases,this paper summarized the relationship between the lung air-blood barrier and lung diseases(including acute lung inju-ry,idiopathic pulmonary fibrosis,chronic obstructive pulmonary disease,etc.)and the progress of TCM treatment,providing new i-deas and methods for the study of the theoretical foundation of lung air-blood barrier in lung diseases.